Cancer-Associated Mucin
نویسندگان
چکیده
منابع مشابه
Clinical evaluation of M43: a novel cancer-associated mucin epitope.
A monoclonal antibody to colon carcinoma mucin was found to react with a colon carcinoma-associated carbohydrate epitope. This antibody was used to develop a quantitative solid phase immunoassay, M43. We prospectively and retrospectively evaluated the assay in patients with and without gastrointestinal carcinoma and compared the sensitivity and specificity with that of carcinoembryonic antigen ...
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Hugo: MUC4 Other names: sv0-MUC4 Location: 3q29 Note: MUC4 belongs to the human mucin family, and more specifically to the subgroup of the membraneanchored mucin. It is an O-glycoprotein that can extend up to 2 micrometer over the cell membrane. It is suggested that MUC4 is translated as a single precursor polypeptide, which is further cleaved at a GDPH site in two subunits, MUC4a and MUC4b. MU...
متن کاملMUC 16 ( mucin 16 , cell surface associated )
As per the present available information, there is a discrepancy regarding the total number of exons present in MUC16 genomic DNA. This discrepancy is due to the absence/presence of some of the genomic sequences (particularly for the repeat regions) in the available genomic databases. The terminal nine exons on both 5' and 3' ends code for the aminoand carboxyterminal domains of MUC16, respecti...
متن کاملAnalysis of cancer-associated colonic mucin by ion-exchange chromatography: evidence for a mucin species of lower molecular charge and weight in cancer.
Cancer-associated mucins in the colon are antigenically distinct and glycosylated differently from their normal counterparts. Mucin-rich glycoconjugate preparations were made from nine non-neoplastic colons, seven colon cancers, and two different xenografts from mucin-producing human colon cancer cell lines, and radiolabeled with 3H. The preparation was applied to a DEAE-cellulose ion-exchange ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1982
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(82)80225-4